| First Author | Chirila AM | Year | 2022 |
| Journal | Cell | Volume | 185 |
| Issue | 24 | Pages | 4541-4559.e23 |
| PubMed ID | 36334588 | Mgi Jnum | J:331718 |
| Mgi Id | MGI:7388015 | Doi | 10.1016/j.cell.2022.10.012 |
| Citation | Chirila AM, et al. (2022) Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain. Cell 185(24):4541-4559.e23 |
| abstractText | The encoding of touch in the spinal cord dorsal horn (DH) and its influence on tactile representations in the brain are poorly understood. Using a range of mechanical stimuli applied to the skin, large-scale in vivo electrophysiological recordings, and genetic manipulations, here we show that neurons in the mouse spinal cord DH receive convergent inputs from both low- and high-threshold mechanoreceptor subtypes and exhibit one of six functionally distinct mechanical response profiles. Genetic disruption of DH feedforward or feedback inhibitory motifs, comprised of interneurons with distinct mechanical response profiles, revealed an extensively interconnected DH network that enables dynamic, flexible tuning of postsynaptic dorsal column (PSDC) output neurons and dictates how neurons in the primary somatosensory cortex respond to touch. Thus, mechanoreceptor subtype convergence and non-linear transformations at the earliest stage of the somatosensory hierarchy shape how touch of the skin is represented in the brain. |
