| First Author | van der Weyden L | Year | 2013 |
| Journal | Oncogene | Volume | 32 |
| Issue | 3 | Pages | 397-402 |
| PubMed ID | 22370638 | Mgi Jnum | J:193376 |
| Mgi Id | MGI:5468242 | Doi | 10.1038/onc.2012.56 |
| Citation | van der Weyden L, et al. (2013) Jdp2 downregulates Trp53 transcription to promote leukaemogenesis in the context of Trp53 heterozygosity. Oncogene 32(3):397-402 |
| abstractText | We performed a genetic screen in mice to identify candidate genes that are associated with leukaemogenesis in the context of Trp53 heterozygosity. To do this we generated Trp53 heterozygous mice carrying the T2/Onc transposon and SB11 transposase alleles to allow transposon-mediated insertional mutagenesis to occur. From the resulting leukaemias/lymphomas that developed in these mice, we identified nine loci that are potentially associated with tumour formation in the context of Trp53 heterozygosity, including AB041803 and the Jun dimerization protein 2 (Jdp2). We show that Jdp2 transcriptionally regulates the Trp53 promoter, via an atypical AP-1 site, and that Jdp2 expression negatively regulates Trp53 expression levels. This study is the first to identify a genetic mechanism for tumour formation in the context of Trp53 heterozygosity. |
