| First Author | Bifari F | Year | 2017 |
| Journal | Cell Stem Cell | Volume | 20 |
| Issue | 3 | Pages | 360-373.e7 |
| PubMed ID | 27889318 | Mgi Jnum | J:253843 |
| Mgi Id | MGI:6101332 | Doi | 10.1016/j.stem.2016.10.020 |
| Citation | Bifari F, et al. (2017) Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex. Cell Stem Cell 20(3):360-373.e7 |
| abstractText | Whether new neurons are added in the postnatal cerebral cortex is still debated. Here, we report that the meninges of perinatal mice contain a population of neurogenic progenitors formed during embryonic development that migrate to the caudal cortex and differentiate into Satb2(+) neurons in cortical layers II-IV. The resulting neurons are electrically functional and integrated into local microcircuits. Single-cell RNA sequencing identified meningeal cells with distinct transcriptome signatures characteristic of (1) neurogenic radial glia-like cells (resembling neural stem cells in the SVZ), (2) neuronal cells, and (3) a cell type with an intermediate phenotype, possibly representing radial glia-like meningeal cells differentiating to neuronal cells. Thus, we have identified a pool of embryonically derived radial glia-like cells present in the meninges that migrate and differentiate into functional neurons in the neonatal cerebral cortex. |
