| First Author | Sullivan RP | Year | 2015 |
| Journal | J Immunol | Volume | 195 |
| Issue | 6 | Pages | 2806-17 |
| PubMed ID | 26268657 | Mgi Jnum | J:317664 |
| Mgi Id | MGI:6843945 | Doi | 10.4049/jimmunol.1500949 |
| Citation | Sullivan RP, et al. (2015) MicroRNA-15/16 Antagonizes Myb To Control NK Cell Maturation. J Immunol 195(6):2806-17 |
| abstractText | NK cells develop in the bone marrow and complete their maturation in peripheral organs, but the molecular events controlling maturation are incompletely understood. The miR-15/16 family of microRNA regulates key cellular processes and is abundantly expressed in NK cells. In this study, we identify a critical role for miR-15/16 in the normal maturation of NK cells using a mouse model of NK-specific deletion, in which immature NK cells accumulate in the absence of miR-15/16. The transcription factor c-Myb (Myb) is expressed preferentially by immature NK cells, is a direct target of miR-15/16, and is increased in 15a/16-1 floxed knockout NK cells. Importantly, maturation of 15a/16-1 floxed knockout NK cells was rescued by Myb knockdown. Moreover, Myb overexpression in wild-type NK cells caused a defective NK cell maturation phenotype similar to deletion of miR-15/16, and Myb overexpression enforces an immature NK cell transcriptional profile. Thus, miR-15/16 regulation of Myb controls the NK cell maturation program. |
