| First Author | Tripathi RB | Year | 2017 |
| Journal | Cell Rep | Volume | 21 |
| Issue | 2 | Pages | 316-323 |
| PubMed ID | 29020619 | Mgi Jnum | J:255244 |
| Mgi Id | MGI:6104081 | Doi | 10.1016/j.celrep.2017.09.050 |
| Citation | Tripathi RB, et al. (2017) Remarkable Stability of Myelinating Oligodendrocytes in Mice. Cell Rep 21(2):316-323 |
| abstractText | New myelin-forming oligodendrocytes (OLs) are generated in the mouse central nervous system during adulthood. These adult-born OLs might augment the existing population, contributing to neural plasticity, or else replace OLs that die in use (turnover). To distinguish between these alternatives, we induced genetic labeling of mature myelinating OLs in young adult mice and tracked their subsequent survival. OL survival rates were region dependent, being higher in corpus callosum ( approximately 90% survival over 20 months) and motor cortex ( approximately 70% survival) than in corticospinal tract or optic nerve (50%-60% survival). Survival rates over the first 8 months were 90%-100% in all regions except the optic nerve. In the corpus callosum, new OLs accumulate during young adulthood and are therefore likely to participate in adaptive myelination. We also found that the number of myelin internodes maintained by individual cortical OLs is stable for at least 8 months but declines approximately 12% in the following year. |
