| First Author | Smith NL | Year | 2018 |
| Journal | Cell | Volume | 174 |
| Issue | 1 | Pages | 117-130.e14 |
| PubMed ID | 29909981 | Mgi Jnum | J:264028 |
| Mgi Id | MGI:6192847 | Doi | 10.1016/j.cell.2018.05.029 |
| Citation | Smith NL, et al. (2018) Developmental Origin Governs CD8(+) T Cell Fate Decisions during Infection. Cell 174(1):117-130.e14 |
| abstractText | Heterogeneity is a hallmark feature of the adaptive immune system in vertebrates. Following infection, naive T cells differentiate into various subsets of effector and memory T cells, which help to eliminate pathogens and maintain long-term immunity. The current model suggests there is a single lineage of naive T cells that give rise to different populations of effector and memory T cells depending on the type and amounts of stimulation they encounter during infection. Here, we have discovered that multiple sub-populations of cells exist in the naive CD8(+) T cell pool that are distinguished by their developmental origin, unique transcriptional profiles, distinct chromatin landscapes, and different kinetics and phenotypes after microbial challenge. These data demonstrate that the naive CD8(+) T cell pool is not as homogeneous as previously thought and offers a new framework for explaining the remarkable heterogeneity in the effector and memory T cell subsets that arise after infection. |
