| First Author | Bénézech C | Year | 2012 |
| Journal | Immunity | Volume | 37 |
| Issue | 4 | Pages | 721-34 |
| PubMed ID | 22940098 | Mgi Jnum | J:188330 |
| Mgi Id | MGI:5440341 | Doi | 10.1016/j.immuni.2012.06.010 |
| Citation | Benezech C, et al. (2012) Lymphotoxin-beta Receptor Signaling through NF-kappaB2-RelB Pathway Reprograms Adipocyte Precursors as Lymph Node Stromal Cells. Immunity 37(4):721-34 |
| abstractText | Lymph node development during embryogenesis involves lymphotoxin-beta receptor engagement and subsequent differentiation of a poorly defined population of mesenchymal cells into lymphoid tissue organizer cells. Here, we showed that embryonic mesenchymal cells with characteristics of adipocyte precursors present in the microenvironment of lymph nodes gave rise to lymph node organizer cells. Signaling through the lymphotoxin-beta receptor controlled the fate of adipocyte precursor cells by blocking adipogenesis and instead promoting lymphoid tissue stromal cell differentiation. This effect involved activation of the NF-kappaB2-RelB signaling pathway and inhibition of the expression of the key adipogenic factors Ppargamma and Cebpalpha. In vivo organogenesis assays show that embryonic and adult adipocyte precursor cells can migrate into newborn lymph nodes and differentiate into a variety of lymph node stromal cells. Thus, we propose that adipose tissues act as a source of lymphoid stroma for lymph nodes and other lymphoid structures associated with fat. |
