| First Author | Kabouridis PS | Year | 2015 |
| Journal | Neuron | Volume | 85 |
| Issue | 2 | Pages | 289-95 |
| PubMed ID | 25578362 | Mgi Jnum | J:262442 |
| Mgi Id | MGI:6109839 | Doi | 10.1016/j.neuron.2014.12.037 |
| Citation | Kabouridis PS, et al. (2015) Microbiota controls the homeostasis of glial cells in the gut lamina propria. Neuron 85(2):289-95 |
| abstractText | The intrinsic neural networks of the gastrointestinal tract are derived from dedicated neural crest progenitors that colonize the gut during embryogenesis and give rise to enteric neurons and glia. Here, we study how an essential subpopulation of enteric glial cells (EGCs) residing within the intestinal mucosa is integrated into the dynamic microenvironment of the alimentary tract. We find that under normal conditions colonization of the lamina propria by glial cells commences during early postnatal stages but reaches steady-state levels after weaning. By employing genetic lineage tracing, we provide evidence that in adult mice the network of mucosal EGCs is continuously renewed by incoming glial cells originating in the plexi of the gut wall. Finally, we demonstrate that both the initial colonization and homeostasis of glial cells in the intestinal mucosa are regulated by the indigenous gut microbiota. |
