| First Author | Jiang C | Year | 2021 |
| Journal | Mol Psychiatry | Volume | 26 |
| Issue | 4 | Pages | 1178-1193 |
| PubMed ID | 31413370 | Mgi Jnum | J:320466 |
| Mgi Id | MGI:6727746 | Doi | 10.1038/s41380-019-0480-7 |
| Citation | Jiang C, et al. (2021) Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward. Mol Psychiatry 26(4):1178-1193 |
| abstractText | Opioids, such as morphine, are clinic analgesics which induce euphoria. Morphine exposure modifies the excitability and functional interactions between neurons, while the underlying cellular and molecular mechanisms, especially how morphine assembles heterogeneous interneurons (INs) in prelimbic cortex (PrL) to mediate disinhibition and reward, are not clear. Using approaches of optogenetics, electrophysiology, and cell type-specific RNA-seq, we show that morphine attenuates the inhibitory synaptic transmission from parvalbumin(+) (PV)-INs onto pyramidal neurons in PrL via mu-opioid receptor (MOR) in PV-INs. Meanwhile, morphine enhances the inhibitory inputs from somatostatin(+) (SST)-INs onto PV-INs, and thus disinhibits pyramidal neurons via delta-opioid receptor (DOR)-dependent Rac1 upregulation in SST-INs. We show that MOR in PV-INs is required for morphine-induced behavioral sensitization, while DOR as well as Rac1 activity in SST-INs is required for morphine-induced conditioned place preference and hyper-locomotion. These results reveal that SST- and PV-INs, functioning in PrL as a disinhibitory architecture, are coordinated by morphine via different opioid receptors to disinhibit pyramidal neurons and enhance reward. |
