| First Author | Shin S | Year | 2020 |
| Journal | Elife | Volume | 9 |
| PubMed ID | 32553115 | Mgi Jnum | J:302360 |
| Mgi Id | MGI:6508207 | Doi | 10.7554/eLife.56189 |
| Citation | Shin S, et al. (2020) Dynamic control of adipose tissue development and adult tissue homeostasis by platelet-derived growth factor receptor alpha. Elife 9:e56189 |
| abstractText | Adipocytes arise from distinct progenitor populations during developmental and adult stages but little is known about how developmental progenitors differ from adult progenitors. Here, we investigate the role of platelet-derived growth factor receptor alpha (PDGFRalpha) in the divergent regulation of the two different adipose progenitor cells (APCs). Using in vivo adipose lineage tracking and deletion mouse models, we found that developmental PDGFRalpha+ cells are adipogenic and differentiated into mature adipocytes, and the deletion of Pdgfra in developmental adipose lineage disrupted white adipose tissue (WAT) formation. Interestingly, adult PDGFRalpha+ cells do not significantly contribute to adult adipogenesis, and deleting Pdgfra in adult adipose lineage did not affect WAT homeostasis. Mechanistically, embryonic APCs require PDGFRalpha for fate maintenance, and without PDGFRalpha, they underwent fate change from adipogenic to fibrotic lineage. Collectively, our findings indicate that PDGFRalpha+ cells and Pdgfra gene itself are differentially required for WAT development and adult WAT homeostasis. |
