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Publication : Light acts through melanopsin to alter retinal waves and segregation of retinogeniculate afferents.

First Author  Renna JM Year  2011
Journal  Nat Neurosci Volume  14
Issue  7 Pages  827-9
PubMed ID  21642974 Mgi Jnum  J:174010
Mgi Id  MGI:5050776 Doi  10.1038/nn.2845
Citation  Renna JM, et al. (2011) Light acts through melanopsin to alter retinal waves and segregation of retinogeniculate afferents. Nat Neurosci 14(7):827-9
abstractText  Waves of correlated activity sweeping across the early postnatal mouse retina promote the segregation and refinement of retinofugal projections. This process has been thought to be spontaneous and unaffected by visual experience. We found, however, that light prolongs spiking during the waves and enhances the segregation of retinogeniculate afferents, and that it did so by activating melanopsin-expressing, intrinsically photosensitive retinal ganglion cells.
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