|  Help  |  About  |  Contact Us

Publication : Light-evoked FOS induction within the suprachiasmatic nuclei (SCN) of melanopsin knockout (Opn4-/-) mice: a developmental study.

First Author  Lupi D Year  2006
Journal  Chronobiol Int Volume  23
Issue  1-2 Pages  167-79
PubMed ID  16687291 Mgi Jnum  J:124726
Mgi Id  MGI:3722473 Doi  10.1080/07420520500545870
Citation  Lupi D, et al. (2006) Light-evoked FOS induction within the suprachiasmatic nuclei (SCN) of melanopsin knockout (Opn4-/-) mice: a developmental study. Chronobiol Int 23(1-2):167-79
abstractText  The aims of this study were to address three related questions: (1) Do the photosensitive ganglion cells of the mouse convey light information to the suprachiasmatic nuclei (SCN) at P0? (2) Do the differentiating rods and cones contribute to light-evoked FOS induction within the murine SCN at P4? (3) How does light-evoked FOS induction within the SCN of melanopsin knockout (Opn4-/-) mice differ at P4 and P14? Our approaches took advantage of the published descriptions of murine ocular development, melanopsin knockout (Opn4-/-) mouse, and light-induced expression of FOS (the phosphoprotein product of immediate early gene c-fos) within the SCN as a marker of retinohypothalamic tract competence. Collectively, our results show that photosensitive melanopsin-dependent retinal ganglion cells provide light information to the murine SCN on the day of birth, and possibly beforehand, and that developing rods and cones fail to provide light information to the SCN during early postnatal life. On the basis of previous publications and data presented here, we suggest that at ages around P14 the rods and cones might be capable of fully compensating for the loss of melanopsin-photosensitive ganglion cells if exposure to light is of sufficiently long duration. These results are related to the broader context of recent findings and the potential role(s) of a neonatal photoreceptor.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

4 Bio Entities

0 Expression