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Publication : A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire.

First Author  Dobeš J Year  2018
Journal  Eur J Immunol Volume  48
Issue  3 Pages  546-548
PubMed ID  29193031 Mgi Jnum  J:258694
Mgi Id  MGI:6144411 Doi  10.1002/eji.201747267
Citation  Dobes J, et al. (2018) A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire. Eur J Immunol 48(3):546-548
abstractText  Medullary thymic epithelial cell (mTEC)-restricted expression of autoimmune regulator (Aire) is essential for establishment of immune tolerance. Recently, Aire was also shown to be expressed in cells of hematopietic and reproductive lineages. Thus, the generation of Aire(fl/fl) mouse strain enables the investigation of the cell-specific function of Aire.
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