| First Author | Jimbo K | Year | 2022 |
| Journal | Leukemia | Volume | 36 |
| Issue | 6 | Pages | 1550-1562 |
| PubMed ID | 35418614 | Mgi Jnum | J:334644 |
| Mgi Id | MGI:7286566 | Doi | 10.1038/s41375-022-01564-7 |
| Citation | Jimbo K, et al. (2022) Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of beta-catenin degradation. Leukemia 36(6):1550-1562 |
| abstractText | The identification of characteristic differences between cancer stem cells and their normal counterparts remains a key challenge for cancer treatment. Here, we investigated the role of immunoglobulin superfamily member 8 (Igsf8, also known as EWI-2, PGRL, and CD316) on normal and malignant hematopoietic stem cells, mainly using the conditional knockout model. Deletion of Igsf8 did not affect steady state hematopoiesis, but it led to a significant improvement of survival in mouse myeloid leukemia models. Deletion of Igsf8 significantly depletes leukemia stem cells (LSCs) through enhanced apoptosis and beta-catenin degradation. At a molecular level, we found that activation of beta-catenin in LSCs depends on Igsf8, which promotes the association of FZD4 with its co-receptor LRP6 in the presence of Igsf8. Similarly, IGSF8 inhibition blocks the colony-forming ability of LSCs and improves the survival of recipients in xenograft models of myeloid leukemia. Collectively, these data indicate strong genetic evidence identifying Igsf8 as a key regulator of myeloid leukemia and the possibility that targeting IGSF8 may serve as a new therapeutic approach against myeloid leukemia. |
