| First Author | Rebourcet D | Year | 2019 |
| Journal | PLoS One | Volume | 14 |
| Issue | 7 | Pages | e0219524 |
| PubMed ID | 31291327 | Mgi Jnum | J:277299 |
| Mgi Id | MGI:6330859 | Doi | 10.1371/journal.pone.0219524 |
| Citation | Rebourcet D, et al. (2019) Relationship of transcriptional markers to Leydig cell number in the mouse testis. PLoS One 14(7):e0219524 |
| abstractText | OBJECTIVES: The current study aims to identify markers that would reflect the number of Leydig cells present in the testis, to help determine whether labour-intensive methods such as stereology are necessary. We used our well-characterised Sertoli cell ablation model in which we have empirically established the size of the Leydig cell population, to try to identify transcriptional biomarkers indicative of population size. RESULTS: Following characterisation of the Leydig cell population after Sertoli cell ablation in neonatal life or adulthood, we identified Hsd3b1 transcript levels as a potential indicator of Leydig cell number with utility for informing decision-making on whether to engage in time-consuming stereological cell counting analysis. |
