| Primary Identifier | MGI:2450312 | Allele Type | Transgenic |
| Attribute String | Inducible, Recombinase | Gene | Tg(Tek-cre/ERT2)1Arnd |
| Strain of Origin | (C57BL/6 x DBA/2) | Induced With | tamoxifen |
| Is Recombinase | true | Is Wild Type | false |
| description | Two transgenic lines displaying endothelial-specific transgene expression, designated L34 and L43, were created. |
| molecularNote | The transgenic construct encodes a tamoxifen-inducible fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand-binding domain fused to the mouse Tek promoter and 10.5 kb of the first intron. Transgene expression in endothelial cells of the liver and kidney was confirmed by immunohistochemical analysis. |
