| First Author | Soderling SH | Year | 2007 |
| Journal | J Neurosci | Volume | 27 |
| Issue | 2 | Pages | 355-65 |
| PubMed ID | 17215396 | Mgi Jnum | J:117303 |
| Mgi Id | MGI:3695976 | Doi | 10.1523/JNEUROSCI.3209-06.2006 |
| Citation | Soderling SH, et al. (2007) A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. J Neurosci 27(2):355-65 |
| abstractText | The scaffolding protein WAVE-1 (Wiskott-Aldrich syndrome protein family member 1) directs signals from the GTPase Rac through the Arp2/3 complex to facilitate neuronal actin remodeling. The WAVE-associated GTPase activating protein called WRP is implicated in human mental retardation, and WAVE-1 knock-out mice have altered behavior. Neuronal time-lapse imaging, behavioral analyses, and electrophysiological recordings from genetically modified mice were used to show that WAVE-1 signaling complexes control aspects of neuronal morphogenesis and synaptic plasticity. Gene targeting experiments in mice demonstrate that WRP anchoring to WAVE-1 is a homeostatic mechanism that contributes to neuronal development and the fidelity of synaptic connectivity. This implies that signaling through WAVE-1 complexes is essential for neural plasticity and cognitive behavior. |
