| First Author | Bromley SK | Year | 2020 |
| Journal | Cell Rep | Volume | 32 |
| Issue | 9 | Pages | 108085 |
| PubMed ID | 32877667 | Mgi Jnum | J:323573 |
| Mgi Id | MGI:6715862 | Doi | 10.1016/j.celrep.2020.108085 |
| Citation | Bromley SK, et al. (2020) CD49a Regulates Cutaneous Resident Memory CD8(+) T Cell Persistence and Response. Cell Rep 32(9):108085 |
| abstractText | CD8(+) tissue-resident memory T cells (TRM) persist at sites of previous infection, where they provide rapid local protection against pathogen challenge. CD8(+) TRM expressing the alpha1 chain (CD49a) of integrin VLA-1 have been identified within sites of resolved skin infection and in vitiligo lesions. We demonstrate that CD49a is expressed early following T cell activation in vivo, and TGF-beta and IL-12 induce CD49a expression by CD8(+) T cells in vitro. Despite this rapid expression, CD49a is not required for the generation of a primary CD8(+) T cell response to cutaneous herpes simplex virus (HSV) infection, migration of CD8(+) T cells across the epidermal basement membrane, or positioning of TRM within basal epidermis. Rather, CD49a supports CD8(+) TRM persistence within skin, regulates epidermal CD8(+) TRM dendritic extensions, and increases the frequency of IFN-gamma(+) CD8(+) TRM following local antigen challenge. Our results suggest that CD49a promotes optimal cutaneous CD8(+) TRM-mediated immunity. |
