Primary Identifier | MGI:2451255 | Allele Type | Targeted |
Attribute String | Humanized sequence, Inserted expressed sequence, Null/knockout | Gene | Apoa1 |
Transmission | Germline | Strain of Origin | 129X1/SvJ |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exons 2 through 4 were either replaced or disrupted by the insertion of human APOA1 exons 2 through 4 via homologous recombination. Whereas murine exons 2 through 3 were replaced by the human sequence for exons 2-4, murine exon 4 was disrupted by a neomycin selection cassette. |