| First Author | Xu L | Year | 2018 |
| Journal | Aging Cell | Volume | 17 |
| Issue | 2 | PubMed ID | 29383825 |
| Mgi Jnum | J:258520 | Mgi Id | MGI:6144393 |
| Doi | 10.1111/acel.12721 | Citation | Xu L, et al. (2018) Ablation of PPARgamma in subcutaneous fat exacerbates age-associated obesity and metabolic decline. Aging Cell 17(2) |
| abstractText | It is well established that aging is associated with metabolic dysfunction such as increased adiposity and impaired energy dissipation; however, the transcriptional mechanisms regulating energy balance during late life stages have not yet been fully elucidated. Here, we show that ablation of the nuclear receptor PPARgamma specifically in inguinal fat tissue in aging mice is associated with increased fat tissue expansion and insulin resistance. These metabolic effects are accompanied by decreased thermogenesis, reduced levels of brown fat genes, and browning of subcutaneous adipose tissue. Comparative studies of the effects of PPARgamma downregulation in young and mid-aged mice demonstrate a preferential regulation of brown fat gene programs in inguinal fat in an age-dependent manner. In conclusion, our study uncovers an essential role for PPARgamma in maintaining energy expenditure during the aging process and suggests the possibility of targeting PPARgamma to counteract age-associated metabolic dysfunction. |
