| First Author | Oshima Y | Year | 2011 |
| Journal | J Am Soc Nephrol | Volume | 22 |
| Issue | 12 | Pages | 2203-12 |
| PubMed ID | 22052048 | Mgi Jnum | J:247475 |
| Mgi Id | MGI:5927456 | Doi | 10.1681/ASN.2011020202 |
| Citation | Oshima Y, et al. (2011) Prorenin receptor is essential for normal podocyte structure and function. J Am Soc Nephrol 22(12):2203-12 |
| abstractText | The prorenin receptor is an accessory subunit of the vacuolar H(+)-ATPase, suggesting that it has fundamental functions beyond activation of the local renin-angiotensin system. Podocytes express the prorenin receptor, but its function in these cells is unknown. Here, podocyte-specific, conditional, prorenin receptor-knockout mice died of kidney failure and severe proteinuria within 4 weeks of birth. The podocytes of these mice exhibited foot process effacement with reduced and altered localization of the slit-diaphragm proteins nephrin and podocin. Furthermore, the podocytes contained numerous autophagic vacuoles, confirmed by enhanced accumulation of microtubule-associated protein 1 light chain 3-positive intracellular vesicles. Ablation of the prorenin receptor selectively suppressed expression of the V(0) c-subunit of the vacuolar H(+)-ATPase in podocytes, resulting in deacidification of intracellular vesicles. In conclusion, the prorenin receptor is important for the maintenance of normal podocyte structure and function. |
