| Primary Identifier | MGI:2450391 | Allele Type | Transgenic |
| Attribute String | Inducible, Recombinase | Gene | Tg(Plp1-cre/ERT)3Pop |
| Strain of Origin | (C57BL/6 x DBA/2)F1 | Induced With | tamoxifen |
| Is Recombinase | true | Is Wild Type | false |
| molecularNote | The transgenic construct encodes a tamoxifen-inducible fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand-binding domain cloned next to a Plp promoter. The 2.5 kb Plp regulatory region includes 5' flanking DNA, exon 1, and intron 1. Transgene expression was confirmed by RT-PCR and Western blot analysis. The mouse Plp promoter was used to drive transgene expression in myelinating cells. |
