| First Author | Pearce G | Year | 2006 |
| Journal | Nat Immunol | Volume | 7 |
| Issue | 8 | Pages | 827-34 |
| PubMed ID | 16845395 | Mgi Jnum | J:112645 |
| Mgi Id | MGI:3662964 | Doi | 10.1038/ni1365 |
| Citation | Pearce G, et al. (2006) Signaling protein SWAP-70 is required for efficient B cell homing to lymphoid organs. Nat Immunol 7(8):827-34 |
| abstractText | The migration of B cells into secondary lymphoid organs is required for the generation of an effective immune response. Here we analyzed the involvement of SWAP-70, a Rac-interacting protein involved in actin rearrangement, in B cell entry into lymph nodes. We noted reduced migration of Swap70-/- B cells into lymph nodes in vivo. Swap70-/- B cells rolled and adhered, yet accumulated in lymph node high endothelial venules. This defect was not due to impaired integrin expression or chemotaxis. Instead, Swap70-/- B cells aberrantly regulated integrin-mediated adhesion. During attachment, Swap70-/- B cells showed defective polarization and did not form uropods or stabilize lamellipodia at a defined region. Thus, SWAP-70 selectively regulates processes essential for B cell entry into lymph nodes. |
