| First Author | Angkasekwinai P | Year | 2010 |
| Journal | Nat Immunol | Volume | 11 |
| Issue | 3 | Pages | 250-6 |
| PubMed ID | 20154671 | Mgi Jnum | J:158594 |
| Mgi Id | MGI:4439211 | Doi | 10.1038/ni.1846 |
| Citation | Angkasekwinai P, et al. (2010) Regulation of IL-9 expression by IL-25 signaling. Nat Immunol 11(3):250-6 |
| abstractText | The physiological regulation of the expression of interleukin (IL)-9, a cytokine traditionally regarded as being T(H)2 associated, remains unclear. Here, we show that IL-9-expressing T cells generated in vitro in the presence of transforming growth factor-beta and IL-4 express high levels of mRNA for IL-17 receptor B (IL-17RB), the receptor for IL-25. Treatment of these cells with IL-25 enhances IL-9 expression in vitro. Moreover, transgenic and retroviral overexpression of IL-17RB in T cells results in IL-25-induced IL-9 production that is IL-4 independent. In vivo, the IL-25-IL-17RB pathway regulates IL-9 expression in allergic airway inflammation. Thus, IL-25 is a newly identified regulator of IL-9 expression. |
