| First Author | Raffatellu M | Year | 2008 |
| Journal | Nat Med | Volume | 14 |
| Issue | 4 | Pages | 421-8 |
| PubMed ID | 18376406 | Mgi Jnum | J:133677 |
| Mgi Id | MGI:3783930 | Doi | 10.1038/nm1743 |
| Citation | Raffatellu M, et al. (2008) Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Nat Med 14(4):421-8 |
| abstractText | Salmonella typhimurium causes a localized enteric infection in immunocompetent individuals, whereas HIV-infected individuals develop a life-threatening bacteremia. Here we show that simian immunodeficiency virus (SIV) infection results in depletion of T helper type 17 (T(H)17) cells in the ileal mucosa of rhesus macaques, thereby impairing mucosal barrier functions to S. typhimurium dissemination. In SIV-negative macaques, the gene expression profile induced by S. typhimurium in ligated ileal loops was dominated by T(H)17 responses, including the expression of interleukin-17 (IL-17) and IL-22. T(H)17 cells were markedly depleted in SIV-infected rhesus macaques, resulting in blunted T(H)17 responses to S. typhimurium infection and increased bacterial dissemination. IL-17 receptor-deficient mice showed increased systemic dissemination of S. typhimurium from the gut, suggesting that IL-17 deficiency causes defects in mucosal barrier function. We conclude that SIV infection impairs the IL-17 axis, an arm of the mucosal immune response preventing systemic microbial dissemination from the gastrointestinal tract. |
