| First Author | Mora-Blanco EL | Year | 2014 |
| Journal | Oncogene | Volume | 33 |
| Issue | 7 | Pages | 933-8 |
| PubMed ID | 23435428 | Mgi Jnum | J:212380 |
| Mgi Id | MGI:5578719 | Doi | 10.1038/onc.2013.37 |
| Citation | Mora-Blanco EL, et al. (2014) Activation of beta-catenin/TCF targets following loss of the tumor suppressor SNF5. Oncogene 33(7):933-8 |
| abstractText | The SWI/SNF chromatin remodeling complex is a master regulator of developmental cell-fate decisions, although the key target pathways are poorly characterized. Here, we interrogated the contribution of the SWI/SNF subunit and tumor suppressor SNF5 to the regulation of developmental pathways using conditional mouse and cell culture models. We find that loss of SNF5 phenocopies beta-catenin hyperactivation and that SNF5 is essential for regulating Wnt/beta-catenin pathway target expression. These data provide insight into chromatin-based mechanisms that underlie developmental regulation and elucidate the emerging theme that mutation of this tumor suppressor complex can activate developmental pathways by uncoupling them from upstream control. |
