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Allele : Tg(Neph1-Vegfa)1Seq transgene insertion 1, Susan E Quaggin

Primary Identifier	MGI:2654006	Allele Type	Transgenic
Attribute String	Inserted expressed sequence	Gene	Tg(Neph1-Vegfa)1Seq
Strain of Origin	Not Specified	Is Recombinase	false
Is Wild Type	false

description	Two trangenic founders exhibiting 30-fold increased Vegfa expression were created.
molecularNote	A mouse Neph1 promoter fused to a Vegfa sequence (164 isoform) was used for the transgene. A 4.125 kb fragment of the mouse Neph1 promoter was used to drive transgene expression in podocytes.

mutations:
Insertion

earliestPublication:
Eremina V, et al. (2003) Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest 111(5):707-16

1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

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