| Primary Identifier | MGI:2655164 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Aqp5 |
| Transmission | Germline | Strain of Origin | 129X1/SvJ |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A 600 bp fragment encompassing exon 3 and surrounding intronic sequence was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded extracellular loop E, which contains the conserved Asn-Pro-Ala motif and the merucury-sensitive cysteine at position 182. Neither transcript nor protein was by analyses of salivary glands obtained from homozygous mutant mice. |
