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Allele : Tg(Prnp)d11Cwe transgene insertion d11, Charles Weissmann
Primary Identifier  MGI:2652550 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(Prnp)d11Cwe
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
description  Two founder lines were generated, D11 and D12.
molecularNote  To define the requirements of Prnp for conferring susceptibility to scrapie, N- terminal deletion mutants of the Prnp genes were constructed in transgenic mice. In this transgenic line, amino acids 32-80 were deleted but the codons for signal sequence and nine additional amino acids were retained to ensure correct processing and cellular localization.
  • mutations:
  • Insertion
  • synonyms:
  • pPrPdeltaN-term,
  • PrPdelta32-80,
  • tgd11,
  • PrPdelta32-80,
  • tgd11,
  • pPrPdeltaN-term
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1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

4 Publication categories





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