| Primary Identifier | MGI:2652765 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Ppp1r15a |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The gene was disrupted by replacement of exon 3 with a PGK-neo cassette via homologous recombination. The targeted mutation deletes residues 549-657 of the PP1c binding domain. Western blot analysis of homozygous mutant fibroblasts detected a truncated protein product. Absence of protein activity was confirmed by immunoprecipitation analysis. |
