| First Author | Pattij T | Year | 2004 |
| Journal | Neurosci Lett | Volume | 354 |
| Issue | 2 | Pages | 169-71 |
| PubMed ID | 14698465 | Mgi Jnum | J:121051 |
| Mgi Id | MGI:3709150 | Doi | 10.1016/j.neulet.2003.10.004 |
| Citation | Pattij T, et al. (2004) Impulsive-like behavior in differential-reinforcement-of-low-rate 36 s responding in mice depends on training history. Neurosci Lett 354(2):169-71 |
| abstractText | Prior behavioral history in operant conditioning paradigms may induce impulsive-like responding as shown in rats. Little is known to what extent behavioral history influences subsequent behavior in mice, therefore the present study investigated the effects of lever-pressing under a fixed-ratio 5 schedule of reinforcement on subsequent differential-reinforcement-of-low-rate (DRL) 36 s performance in wild type mice compared to the behavior of 5-HT1B receptor knockout mice. Acquisition of both autoshaping and fixed-ratio 5 training was faster in 5-HT1B receptor knockout compared to wild type mice. Nevertheless, in the DRL 36 s procedure no differences were observed between genotypes. Both wild type and 5-HT1B receptor knockout mice displayed premature or impulsive-like responding in the DRL 36 s procedure, for example a peak location of responses around 20 s and high rates of responding. Taken together, the present data suggest that impulsive-like responding in the DRL 36 s procedure in mice depends on prior behavioral history. |
