| First Author | Belzung C | Year | 2000 |
| Journal | Pharmacol Biochem Behav | Volume | 66 |
| Issue | 1 | Pages | 221-5 |
| PubMed ID | 10837864 | Mgi Jnum | J:102804 |
| Mgi Id | MGI:3608087 | Doi | 10.1016/s0091-3057(00)00238-0 |
| Citation | Belzung C, et al. (2000) Absence of cocaine-induced place conditioning in serotonin 1B receptor knock-out mice. Pharmacol Biochem Behav 66(1):221-5 |
| abstractText | A large body of evidence suggests that genetic factors may affect the reinforcing properties of drugs of abuse. This study investigated the involvement of the serotonin 1B (5-HT1B) receptor in modulating cocaine-induced place conditioning by comparing the response of 5-HT1B receptor gene knock-out mice with wild type 129/Sv-ter mice. The rewarding effects of various doses of cocaine (0, 2.5, 5, 10, 20, and 40 mg/kg) were examined in both strains. Results clearly show that 5-HT1B receptor knock-out mice failed to display a conditioned place preference for stimuli paired with cocaine while wild type mice exhibited a conditioned place preference for the compartment paired with cocaine (5 and 20 mg/kg). As other studies showed that 5-HT1B knock-out mice self-administer cocaine, these results suggest a dissociation between the psychologic state linked to self-administration and the one measured in conditioned place preference. |
