| First Author | Long JZ | Year | 2014 |
| Journal | Cell Metab | Volume | 19 |
| Issue | 5 | Pages | 810-20 |
| PubMed ID | 24709624 | Mgi Jnum | J:214781 |
| Mgi Id | MGI:5603994 | Doi | 10.1016/j.cmet.2014.03.025 |
| Citation | Long JZ, et al. (2014) A smooth muscle-like origin for beige adipocytes. Cell Metab 19(5):810-20 |
| abstractText | Thermogenic UCP1-positive cells, which include brown and beige adipocytes, transform chemical energy into heat and increase whole-body energy expenditure. Using a ribosomal profiling approach, we present a comprehensive molecular description of brown and beige gene expression from multiple fat depots in vivo. This UCP1-TRAP data set demonstrates striking similarities and important differences between these cell types, including a smooth muscle-like signature expressed by beige, but not classical brown, adipocytes. In vivo fate mapping using either a constitutive or an inducible Myh11-driven Cre demonstrates that at least a subset of beige cells arise from a smooth muscle-like origin. Finally, ectopic expression of PRDM16 converts bona fide vascular smooth muscle cells into Ucp1-positive adipocytes in vitro. These results establish a portrait of brown and beige adipocyte gene expression in vivo and identify a smooth muscle-like origin for beige cells. |
