| First Author | Morimatsu M | Year | 1998 |
| Journal | Cancer Res | Volume | 58 |
| Issue | 15 | Pages | 3441-7 |
| PubMed ID | 9699678 | Mgi Jnum | J:49518 |
| Mgi Id | MGI:1277623 | Citation | Morimatsu M, et al. (1998) Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to gamma-radiation and premature senescence. Cancer Res 58(15):3441-7 |
| abstractText | The putative Brca2-MmRad51 interaction is analyzed in mouse cells deleted for the COOH terminus of Brca2 (amino acids 3140-3328), which contains a region that associates with MmRad51 by yeast two-hybrid. These cells are hypersensitive to gamma-radiation (suggesting defective recombinational repair) but not UV light (suggesting intact nucleotide excision repair) and maintain the G(1)-S and G(2)-M checkpoints after exposure to gamma- irradiation. Cells deleted for the COOH terminus of Brca2 progress through the cell cycle at a similar rate as wild- type cells but undergo senescence more rapidly. These data support the hypothesis that deletion of Brca2 stimulates cancer by defective MmRad51-mediated DNA repair and not by defective cell cycle regulation. |
