| First Author | Taniguchi T | Year | 1997 |
| Journal | Lab Invest | Volume | 77 |
| Issue | 6 | Pages | 647-58 |
| PubMed ID | 9426403 | Mgi Jnum | J:44841 |
| Mgi Id | MGI:1101387 | Citation | Taniguchi T, et al. (1997) Failure of germinal center formation and impairment of response to endotoxin in tumor necrosis factor alpha-deficient mice. Lab Invest 77(6):647-58 |
| abstractText | To study the pathophysiologic roles of TNF alpha, we produced TNF alpha gene-disrupted mice by gene targeting. TNF alpha-deficient mice develop normally without any alteration in the lymphocyte populations. However, in these mice, the germinal center formation in the peripheral lymphoid organs failed in response to the T cell-dependent antigens. TNF alpha-deficient mice are resistant to lethal doses of endotoxin and D-galactosamine without hepatocyte apoptosis, yet demonstrate thymus apoptosis. Our results indicated an important role for TNF alpha in germinal center formation and in the sepsis-induced hepatocyte apoptosis that precedes liver failure. |
