| First Author | Regateiro FS | Year | 2011 |
| Journal | Eur J Immunol | Volume | 41 |
| Issue | 10 | Pages | 2955-65 |
| PubMed ID | 21770045 | Mgi Jnum | J:176801 |
| Mgi Id | MGI:5292770 | Doi | 10.1002/eji.201141512 |
| Citation | Regateiro FS, et al. (2011) Generation of anti-inflammatory adenosine byleukocytes is regulated by TGF-beta. Eur J Immunol 41(10):2955-65 |
| abstractText | Levels of anti-inflammatory extracellular adenosine are controlled by the sequential action of the ectonucleotidases CD39 and CD73, whose expression in CD4(+) T cells has been associated with natural regulatory T cells (nTregs). We here show that CD73 expression on activated murine CD4(+) T cells is induced by TGF-beta independently of Foxp3 expression, operates at the transcriptional level and translates into gain of functional capacity to generate adenosine. In the presence of AMP, CD73 induced by TGF-beta generates adenosine able to suppress proliferation of activated CD4(+) T cells in vitro. These effects are contextual and opposed by proinflammatory cytokines. CD73 is also upregulated by TGF-beta in CD8(+) T cells, DCs and macrophages, so providing an amplification mechanism for adenosine generation in tissue microenvironments. Together, these findings expose a novel anti-inflammatory role for TGF-beta. |
