| First Author | Gasteiger G | Year | 2013 |
| Journal | J Exp Med | Volume | 210 |
| Issue | 6 | Pages | 1179-87 |
| PubMed ID | 23650439 | Mgi Jnum | J:200963 |
| Mgi Id | MGI:5510314 | Doi | 10.1084/jem.20122571 |
| Citation | Gasteiger G, et al. (2013) IL-2-dependent adaptive control of NK cell homeostasis. J Exp Med 210(6):1179-87 |
| abstractText | Activation and expansion of T and B lymphocytes and myeloid cells are controlled by Foxp3(+) regulatory T cells (T reg cells), and their deficiency results in a fatal lympho- and myeloproliferative syndrome. A role for T reg cells in the homeostasis of innate lymphocyte lineages remained unknown. Here, we report that T reg cells restrained the expansion of immature CD127(+) NK cells, which had the unique ability to up-regulate the IL2Ralpha (CD25) in response to the proinflammatory cytokine IL-12. In addition, we observed the preferential accumulation of CD127(+) NK cells in mice bearing progressing tumors or suffering from chronic viral infection. CD127(+) NK cells expanded in an IL-2-dependent manner upon T reg cell depletion and were able to give rise to mature NK cells, indicating that the latter can develop through a CD25(+) intermediate stage. Thus, T reg cells restrain the IL-2-dependent CD4(+) T cell help for CD127(+) immature NK cells. These findings highlight the adaptive control of innate lymphocyte homeostasis. |
