| First Author | del Barco Barrantes I | Year | 2011 |
| Journal | Proc Natl Acad Sci U S A | Volume | 108 |
| Issue | 31 | Pages | 12764-9 |
| PubMed ID | 21768366 | Mgi Jnum | J:176023 |
| Mgi Id | MGI:5288131 | Doi | 10.1073/pnas.1015013108 |
| Citation | del Barco Barrantes I, et al. (2011) Genetic analysis of specific and redundant roles for p38alpha and p38beta MAPKs during mouse development. Proc Natl Acad Sci U S A 108(31):12764-9 |
| abstractText | p38alpha MAPK is an important regulator of cellular responses induced by external cues, but the elucidation of physiological functions for p38alpha has been complicated by the possible functional redundancy in vivo with the related family member p38beta. We found that mice with combined deletion of p38alpha and p38beta display diverse developmental defects at midgestation, including major cardiovascular abnormalities, which are observed neither in single knockout nor in double heterozygous embryos. Expression analysis indicates specific functions of p38alpha and p38beta in the regulation of cardiac gene expression during development. By using knock-in animals that express p38beta under control of the endogenous p38alpha promoter, we also found that p38beta cannot perform all of the functions of p38alpha during embryogenesis. Our results identify essential roles for p38alpha and p38beta during development and suggest that some specific functions may be explained by differences in expression patterns. |
