| First Author | Geisberger S | Year | 2015 |
| Journal | Blood | Volume | 126 |
| Issue | 4 | Pages | 504-7 |
| PubMed ID | 26063165 | Mgi Jnum | J:226359 |
| Mgi Id | MGI:5697128 | Doi | 10.1182/blood-2015-03-635292 |
| Citation | Geisberger S, et al. (2015) New role for the (pro)renin receptor in T-cell development. Blood 126(4):504-7 |
| abstractText | The (pro)renin receptor (PRR) was originally thought to be important for regulating blood pressure via the renin-angiotensin system. However, it is now emerging that PRR has instead a generic role in cellular development. Here, we have specifically deleted PRR from T cells. T-cell-specific PRR-knockout mice had a significant decrease in thymic cellularity, corresponding with a 100-fold decrease in the number of CD4(+) and CD8(+) thymocytes, and a large increase in double-negative (DN) precursors. Gene expression analysis on sorted DN3 thymocytes indicated that PRR-deficient thymocytes have perturbations in key cellular pathways essential at the DN3 stage, including transcription and translation. Further characterization of DN T-cell progenitors leads us to propose that PRR deletion affects thymocyte survival and development at multiple stages; from DN3 through to DN4, double-positive, and single-positive CD4 and CD8. Our study thus identifies a new role for PRR in T-cell development. |
