| First Author | Gebre-Medhin S | Year | 1998 |
| Journal | Brain Res Mol Brain Res | Volume | 63 |
| Issue | 1 | Pages | 180-3 |
| PubMed ID | 9838101 | Mgi Jnum | J:51556 |
| Mgi Id | MGI:1316900 | Doi | 10.1016/s0169-328x(98)00269-1 |
| Citation | Gebre-Medhin S, et al. (1998) Reduced nociceptive behavior in islet amyloid polypeptide (amylin) knockout mice. Brain Res Mol Brain Res 63(1):180-3 |
| abstractText | Islet amyloid polypeptide (IAPP or amylin) is predominantly expressed by insulin cells, but occurs also in primary sensory neurons in the rat. Here, using mice targeted for a null mutation in the IAPP gene, we establish murine expression of IAPP in sensory neurons; its distribution in a population of calcitonin gene-related peptide- containing neurons in the spinal cord and dorsal root ganglion is similar to that previously described in the rat. We also report the IAPP mutant mice display a reduced pain response in the paw formalin test. Adjuvant-induced joint inflammation was not altered in IAPP mutants, arguing against a peripheral inflammatory abnormality. These findings lead us to suggest that IAPP has a pro-nociceptive function in primary sensory neurons. Copyright 1998 Elsevier Science B.V. |
