| First Author | Cook R | Year | 2003 |
| Journal | Brain Res Mol Brain Res | Volume | 110 |
| Issue | 2 | Pages | 279-88 |
| PubMed ID | 12591164 | Mgi Jnum | J:82236 |
| Mgi Id | MGI:2651797 | Doi | 10.1016/s0169-328x(02)00659-9 |
| Citation | Cook R, et al. (2003) Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice. Brain Res Mol Brain Res 110(2):279-88 |
| abstractText | The loss of substantia nigra pars compacta (SNpc) neurons seen in idiopathic Parkinson's disease is hypothesized to result from a genetic susceptibility to an unknown environmental toxin. MPTP has been used as a prototypical toxin, since exposure to this drug results in variable SNpc cell death in several vertebrate species, including man and mouse. Previously, we have shown that C57BL/6J mice are sensitive to this compound, while Swiss-Webster mice are resistant. In this study, we intercrossed these mouse strains to map quantitative trait loci (QTL) for MPTP sensitivity. Using genome wide PCR analysis, we found that a single major QTLs, Mptp1, located near the distal end of chromosome 1 between D1Mit113 and D1Mit293, accounts for the majority of the strain sensitivity to MPTP. |
