| First Author | Marik SA | Year | 2013 |
| Journal | J Neurosci | Volume | 33 |
| Issue | 38 | Pages | 14998-5003 |
| PubMed ID | 24048829 | Mgi Jnum | J:202324 |
| Mgi Id | MGI:5518488 | Doi | 10.1523/JNEUROSCI.2398-13.2013 |
| Citation | Marik SA, et al. (2013) Death receptor 6 regulates adult experience-dependent cortical plasticity. J Neurosci 33(38):14998-5003 |
| abstractText | Sensory experience alters cortical circuitry by parallel processes of axon outgrowth and pruning, but the mechanisms that control these rearrangements are poorly understood. Using in vivo 2-photon longitudinal imaging, we found a marked reduction in axonal pruning in somatosensory cortex of mice with a knock-out of the DR6 gene, which codes for Death Receptor 6. This effect was seen for both long-range horizontal excitatory connections and for the axons of inhibitory neurons. These results identify a new pathway governing axonal plasticity associated with experience-dependent changes in cortical maps. |
