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Allele : H2<dlAb1-Ea> histocompatibility-2, MHC; targeted deletion, H2 complex
Primary Identifier  MGI:2658725 Allele Type  Targeted
Attribute String  Null/knockout Gene  H2
Transmission  Germline Strain of Origin  129S2/SvPas
Is Recombinase  false Is Wild Type  false
molecularNote  A 78.8 kb deletion disrupting Class II MHC genes was induced in 129S2/SvPas-derived H1 embryonic stem (ES) cells via Cre recombination. A hygro-resistance cassette was inserted at the deletion site. The deletion spans from the second exon of the H2-Ab1 gene the third exon of the H2-Ea gene. The H2-Aa, H2-Eb1 and H2-Eb2 genes are completely deleted.
  • mutations:
  • Intergenic deletion
  • synonyms:
  • MHC II<delta>,
  • MHC class II<delta>,
  • MHCII<->,
  • ABeta<o>,
  • II<delta>,
  • MHC II<0>,
  • ABeta<o>,
  • MHC-II<delta>,
  • (IA IE)<null>,
  • MHC II<0>,
  • MHCII<delta>,
  • MHC II<->,
  • MHCII<->,
  • MHC II KO,
  • MHC II KO,
  • II<delta>,
  • MHC class II<delta>,
  • MHCII<delta>,
  • MHC II<->,
  • MHC-II<delta>,
  • (IA IE)<null>,
  • MHC II<delta>
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1 Feature

Genome

0 Expresses

5 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

5 Carried By

0 Driven By

232 Publication categories





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