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Allele : Hpgd<tm1Bhk> hydroxyprostaglandin dehydrogenase 15 (NAD); targeted mutation 1, Beverly H Koller

Primary Identifier  MGI:2657242 Allele Type  Targeted
Attribute String  Null/knockout Gene  Hpgd
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
description  Phenotypic Similarity to Human Syndrome: Patent Ductus Arteriosus in homozygous mice (J:74466)
molecularNote  The gene was disrupted by replacement of sequences corresponding to amino acids 167-266 of the human protein with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis of lung and liver RNA.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • Pgdh<->,
  • Pgdh<->
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

12 Publication categories