| First Author | Noto MJ | Year | 2015 |
| Journal | Infect Immun | Volume | 83 |
| Issue | 10 | Pages | 4134-41 |
| PubMed ID | 26238713 | Mgi Jnum | J:233099 |
| Mgi Id | MGI:5780779 | Doi | 10.1128/IAI.00410-15 |
| Citation | Noto MJ, et al. (2015) Toll-Like Receptor 9 Contributes to Defense against Acinetobacter baumannii Infection. Infect Immun 83(10):4134-41 |
| abstractText | Acinetobacter baumannii is a common nosocomial pathogen capable of causing severe diseases associated with significant morbidity and mortality in impaired hosts. Pattern recognition receptors, such as the Toll-like receptors (TLRs), play a key role in pathogen detection and function to alert the immune system to infection. Here, we examine the role for TLR9 signaling in response to A. baumannii infection. In a murine model of A. baumannii pneumonia, TLR9(-/-) mice exhibit significantly increased bacterial burdens in the lungs, increased extrapulmonary bacterial dissemination, and more severe lung pathology compared with those in wild-type mice. Following systemic A. baumannii infection, TLR9(-/-) mice have significantly increased bacterial burdens in the lungs, as well as decreased proinflammatory cytokine and chemokine production. These results demonstrate that TLR9-mediated pathogen detection is important for host defense against the opportunistic pathogen Acinetobacter baumannii. |
