| First Author | Erlandsson L | Year | 1998 |
| Journal | Curr Biol | Volume | 8 |
| Issue | 4 | Pages | 223-6 |
| PubMed ID | 9501984 | Mgi Jnum | J:83172 |
| Mgi Id | MGI:2657117 | Doi | 10.1016/s0960-9822(98)70086-7 |
| Citation | Erlandsson L, et al. (1998) Interferon-beta is required for interferon-alpha production in mouse fibroblasts. Curr Biol 8(4):223-6 |
| abstractText | The type I interferons--interferon-alpha (IFN-alpha) and interferon-beta (IFN-beta)--are critical for protection against viruses during the acute stage of viral infection [1,2]. Furthermore, type I interferons have been implicated as important mediators in the regulation of lymphocyte development [3], immune responses [4,5] and the maintenance of immunological memory of cytotoxic T cells [6,7]. The different IFN-alpha subtypes are encoded by 12 genes in the mouse [8] whereas IFN-beta is encoded by only one gene [9]. IFN-alpha and IFN-beta have a high degree of sequence homology and are thought to interact with the same surface receptor on target cells [10,11]. As an approach to analysing the different biological functions of IFN-alpha and IFN-beta, we have generated a mouse strain with an inactivated IFN-beta gene. We report here that embryonic fibroblasts from such mice produce neither IFN-beta nor IFN-alpha upon Sendal virus infection, whereas the production of IFN-alpha by leukocytes from the same strain of mice is intact. IFN-alpha production in embryonic fibroblasts from IFN-beta-/- mice could be rescued by 'priming' the cells using exogenous IFN-beta. These results imply a unique role for IFN-beta in the induction of type I interferons in peripheral tissues. |
