| First Author | Mancuso G | Year | 2009 |
| Journal | Nat Immunol | Volume | 10 |
| Issue | 6 | Pages | 587-94 |
| PubMed ID | 19430477 | Mgi Jnum | J:149541 |
| Mgi Id | MGI:3848655 | Doi | 10.1038/ni.1733 |
| Citation | Mancuso G, et al. (2009) Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells. Nat Immunol 10(6):587-94 |
| abstractText | Little is known of how and where bacterial recognition triggers the induction of type I interferon. Whether the type of recognition receptor used in these responses is determined by the subcellular location of bacteria is not understood. Here we show that phagosomal bacteria such as group B streptococcus, but not cytosolic bacteria, potently induced interferon in conventional dendritic cells by a mechanism that required Toll-like receptor 7, the adaptor MyD88 and the transcription factor IRF1, all of which localized together with bacterial products in degradative vacuoles bearing lysosomal markers. Thus, this cell type-specific recognition pathway links lysosomal recognition of bacterial RNA with a robust, host-protective interferon response. |
