| First Author | Trinh K | Year | 2003 |
| Journal | Nat Neurosci | Volume | 6 |
| Issue | 5 | Pages | 519-25 |
| PubMed ID | 12665798 | Mgi Jnum | J:83156 |
| Mgi Id | MGI:2657084 | Doi | 10.1038/nn1039 |
| Citation | Trinh K, et al. (2003) Vomeronasal organ detects odorants in absence of signaling through main olfactory epithelium. Nat Neurosci 6(5):519-25 |
| abstractText | It is commonly assumed that odorants are detected by the main olfactory epithelium (MOE) and pheromones are sensed through the vomeronasal organ (VNO). The complete loss of MOE-mediated olfaction in type-3 adenylyl cyclase knockout mice (AC3-/-) allowed us to examine chemosensory functions of the VNO in the absence of signaling through the MOE. Here we report that AC3-/- mice are able to detect certain volatile odorants via the VNO. These same odorants elicited electro-olfactogram transients in the VNO and MOE of wild-type mice, but only VNO responses in AC3-/- mice. This indicates that some odorants are detected through an AC3-independent pathway in the VNO. |
