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Allele : Trp53bp1<Gt(OST94324)Lex> transformation related protein 53 binding protein 1; gene trap OST94324, Lexicon Genetics

Primary Identifier  MGI:2661096 Allele Type  Gene trapped
Attribute String  Null/knockout, Reporter Gene  Trp53bp1
Transmission  Germline Strain of Origin  129S5/SvEvBrd
Is Recombinase  false Is Wild Type  false
Project Collection  Lexicon
molecularNote  The gene trap vector VICTR54 inserted into the intron between exons 13 and 14 resulting in premature stop codons downstream. RT-PCR analysis showed that exon 13 failed to properly splice next to exon 14. The expressed protein lacks over 700 residues, which include the functional nuclear localization signal, kinetochore binding domain, and 2 BRCT motifs.
  • mutations:
  • Insertion of gene trap vector
  • synonyms:
  • Trp53bp1<Gt(neo)531Lex>,
  • m53BP1<tr>,
  • Trp53bp1<Gt(VICTR54)19Lex>,
  • 53BP1<->,
  • 53BP1<->,
  • Trp53bp1<Gt(neo)531Lex>,
  • m53BP1<tr>,
  • Trp53bp1<Gt(VICTR54)19Lex>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

12 Publication categories