| Primary Identifier | MGI:2661195 | Allele Type | QTL |
| Gene | Lmr14 | Inheritance Mode | Other (see notes) |
| Strain of Origin | BALB/cHeA | Is Recombinase | false |
| Is Wild Type | false |
| description | Lmr14 exhibits additive inheritance. Homozygosity for BALB/cHeA alleles at Lmr12 and Lmr14 confers increased serum TNF-alpha. Eache locus has minimal effect by itself. |
| molecularNote | Lmr14 was identified influencing IgE level in interaction with Lmr25 on mouse Chromosome 10. BALB/c homozygotes at Lmr25 and STS/A homozygotes at Lmr14 or combination of BALB/c homozygtes at these loci resulted in increased IgE levels. This allele also confer increased spontaneous in vitro splenocyte proliferation of Leishmania infected animals compared to STS/A. |
